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KMID : 0391520140220040195
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Journal of the Korean Child Neurology Society
2014 Volume.22 No. 4 p.195 ~ p.201
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Treatment of Benign Epilepsy with Centrotemporal Spikes: Effectiveness of Low-dose Topiramate at night therapy in Benign Epilepsy with Centrotemporal Spikes
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Kim Byoung-Young
Oh Ha-Jin
Choi Young-Earl
Park Soo-Min
Cho Hwa-Jin
Kim Young-Ok
Woo Young-Jong
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Abstract
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Purpose: Benign epilepsy with centrotemporal spikes (BECTS) is a benign disease which requires treatment with minimal side effects. The purpose of this study is to evaluate the effectiveness and efficacy of low dose topiramate (TPM), single dose, at night therapy.
Method: We have reviewed the results of low dose TPM, single dose, at night therapy in BECTS who were treated from Oct. 2009 to Jul. 2014, and compared that with those of the treatment with oxcarbazepine (OXC) from Jan. 2003 to Nov. 2010.
Results: Among the patients with single dose of TPM (n=23), the symptoms of 18 patients (78.2%) were controlled with TPM only and 5 patients (21.8%) were controlled with TPM with OXC. Among the patients with OXC therapy (n=63), the symptoms of 46 patients (73.1%) were controlled. Among these patients, 5 patients were converted to TPM therapy for the continued electroencephalogram (EEG) abnormality. The symptoms of 17 patients (26.9%) were controlled with add on therapy (TPM in 13 patients and Lamotrigine in 4). The duration of nomalized EEG of TPM therapy was shoter than those of OXC therapy. The side effects of OXC were skin rash in 3, weight gain in 3, and decreased memory in 1 patient. In TPM patients, decreased sweating was reported in 1 patient.
Conclusion: In BECTS patients, single, low dose of TPM is as effective as OXC therapy. Also, it has better compliance with lesser side effects.
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KEYWORD
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Benign Epilepsy with Centrotemporal Spikes (BECTS), Low dose topiramate
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